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ADAM17 antibody

别称:ADAM 17 antibody, ADAM17 antibody, CD156b antibody, cSVP antibody, Snake venom like protease antibody, TACE antibody, TNF alpha convertase antibody, TNF alpha converting enzyme antibody
货号:FNab00138反应性:Human, Mouse, Rat
宿主:Rabbit验证实验:ELISA, WB, IHC
克隆性:polyclonal亚型:IgG
¥1750
规格:
货期: 三个工作日+顺丰快递时长
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产品名称
ADAM17 antibody
货号
FNab00138
规格
100μg
状态
liquid
纯化方法
Immunogen affinity purified
纯度
≥95% as determined by SDS-PAGE
克隆性
polyclonal
亚型
IgG
存储
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
免疫原信息
免疫原
ADAM metallopeptidase domain 17
别称
ADAM 17 antibody, ADAM17 antibody, CD156b antibody, cSVP antibody, Snake venom like protease antibody, TACE antibody, TNF alpha convertase antibody, TNF alpha converting enzyme antibody
UniProt ID
P78536
分子量
115 kDa
验证实验
验证实验
ELISA, WB, IHC
建议稀释比例
WB: 1:500 - 1:2000; IHC: 1:100 - 1:200
验证图片
U-937 cells were subjected to SDS PAGE followed by western blot with FNab00138( ADAM17 Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded rat heart tissue slide using FNab00138( ADAM17 Antibody) at dilution of 1:100?
背景介绍
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands. The encoded protein also plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types derived from psoriasis, rheumatoid arthritis, multiple sclerosis and Crohn's disease patients, suggesting that the encoded protein may play a role in autoimmune disease.
IF: 5.4
期刊名:
Journal of Ethnopharmacology
作者:
Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, 211198, PR China
发布日期:
2023-11-10
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