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IL-17 antibody

别称:CTLA 8 antibody, CTLA8 antibody, IL 17 antibody, IL 17A antibody, IL17 antibody, IL-17 antibody, IL17A antibody, interleukin 17A antibody
货号:FNab04225反应性:Human
宿主:Mouse验证实验:ELISA, WB, FC
克隆性:monoclonal亚型:IgG1
¥1750
规格:
货期: 三个工作日+顺丰快递时长
  • 产品介绍
产品名称
IL-17 antibody
货号
FNab04225
规格
100μg
状态
liquid
纯化方法
Protein A+G purification
纯度
≥95% as determined by SDS-PAGE
克隆性
monoclonal
亚型
IgG1
Clone ID
5E2
存储
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
免疫原信息
免疫原
interleukin 17A
别称
CTLA 8 antibody, CTLA8 antibody, IL 17 antibody, IL 17A antibody, IL17 antibody, IL-17 antibody, IL17A antibody, interleukin 17A antibody
UniProt ID
Q16552
分子量
18 kDa
验证实验
验证实验
ELISA, WB, FC
建议稀释比例
WB: 1:500-1:1000
验证图片
U-937 cells were subjected to SDS PAGE followed by western blot with FNab04225(IL-17 antibody) at dilution of 1:500
背景介绍
IL17A, also named as IL-17, is a proinflammatory cytokine. IL-17, synthesized only by memory T cells and natural killer cells, has pleiotropic effects, mainly in the recruitment and activation of neutrophils. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2(PTGS2/COX-2), as well as enhance the production of nitric oxide(NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The IL-17 receptor is a type I transmembrane protein, that is widely expressed on epithelial cells, fibroblasts, B and T cells, and monocytic cells. In psoriatic skin lesions, both Th17 cells and their downstream effector molecules, e.g. IL-17 and IL-22, are highly increased.