产品
本公司产品仅供体外研究使用，不用于临床诊断
USP11 antibody
¥2100
规格：
货期：
三个工作日+顺丰&京东快递时长
- 产品名称
- USP11 antibody
- 货号
- FNab09306
- 规格
- 100μg
- 状态
- liquid
- 纯化方法
- Immunogen affinity purified
- 纯度
- ≥95% as determined by SDS-PAGE
- 克隆性
- polyclonal
- 亚型
- IgG
- 存储
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
免疫原信息
- 免疫原
- ubiquitin specific peptidase 11
- 别称
- Deubiquitinating enzyme 11 antibody, Ubiquitin thiolesterase 11 antibody, UHX1 antibody, USP11 antibody
- UniProt ID
- P51784
- 分子量
- 110 kDa
验证实验
- 验证实验
- ELISA, WB, IHC, IP
- 建议稀释比例
- WB: 1:500-1:1000; IP: 1:200-1:1000; IHC: 1:50-1:500
验证图片
Jurkat cells were subjected to SDS PAGE followed by western blot with FNab09306(USP11 antibody) at dilution of 1:1000
IP Result of anti-USP11 (IP:FNab09306, 4ug; Detection:FNab09306 1:2000) with HEK-293 cells lysate 2400ug.
Immunohistochemistry of paraffin-embedded human colon cancer tissue slide using FNab09306(USP11 Antibody) at dilution of 1:50
- 背景介绍
- Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains(PubMed:12084015, PubMed:15314155, PubMed:17897950, PubMed:19874889, PubMed:20233726, PubMed:24724799). Inhibits the degradation of target proteins by the proteasome(PubMed:12084015). Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains(in vitro)(PubMed:24724799). Plays a role in the regulation of pathways leading to NF-kappa-B activation(PubMed:17897950, PubMed:19874889). Plays a role in the regulation of DNA repair after double-stranded DNA breaks(PubMed:15314155, PubMed:20233726).
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