产品
本公司产品仅供体外研究使用，不用于临床诊断
USP5 antibody
¥1900
规格：
货期：
三个工作日+顺丰&京东快递时长
- 产品名称
- USP5 antibody
- 货号
- FNab09340
- 规格
- 100μg
- 状态
- liquid
- 纯化方法
- Immunogen affinity purified
- 纯度
- ≥95% as determined by SDS-PAGE
- 克隆性
- polyclonal
- 亚型
- IgG
- 存储
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
免疫原信息
- 免疫原
- ubiquitin specific peptidase 5(isopeptidase T)
- 别称
- Deubiquitinating enzyme 5 antibody, Isopeptidase T antibody, ISOT antibody, Ubiquitin thiolesterase 5 antibody, USP5 antibody
- UniProt ID
- P45974
- 分子量
- 93 kDa
验证实验
- 验证实验
- ELISA, WB
- 建议稀释比例
- WB: 1:1000-1:2000
验证图片
A549 cells were subjected to SDS PAGE followed by western blot with FNab09340(USP5 antibody) at dilution of 1:1000
- 背景介绍
- Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.
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