产品
本公司产品仅供体外研究使用，不用于临床诊断
beta-Catenin antibody
¥1900
规格：
货期：
三个工作日+顺丰&京东快递时长
- 产品名称
- beta-Catenin antibody
- 货号
- FNab09871
- 规格
- 100μg
- 状态
- liquid
- 纯化方法
- protein A+G purified
- 纯度
- ≥95% as determined by SDS-PAGE
- 克隆性
- monoclonal
- 亚型
- IgG1
- Clone ID
- 5D7
- 存储
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
免疫原信息
- 免疫原
- catenin(cadherin-associated protein), beta 1, 88kDa
- 别称
- b cat antibody, Beta catenin antibody, beta-Catenin antibody, Catenin beta 1 antibody, CTNNB antibody, CTNNB1 antibody, PRO2286 antibody, β catenin antibody, β-catenin antibody
- UniProt ID
- P35222
- 分子量
- 90 kDa
验证实验
- 验证实验
- ELISA, IF, WB, IHC, IP
- 建议稀释比例
- WB: 1:2000-1:20000; IP: 1:1000-1:5000; IHC: 1:200-1:1000; IF: 1:20-1:500
验证图片
A431 cells were subjected to SDS PAGE followed by western blot with FNab09781(B-catenin antibody) at dilution of 1:5000
IP Result of anti-beta-Catenin (IP:FNab09871, 4ug; Detection:FNab09871 1:500) with mouse liver tissue lysate 6400ug.
Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using FNab09781(B-catenin Antibody) at dilution of 1:200
- 背景介绍
- The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants.
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