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VEGF antibody

别称:L VEGFA antibody, MVCD1 antibody, Vascular permeability factor antibody, VEGF antibody, VEGF A antibody, VEGFA antibody, VPF antibody
货号:FNab09933反应性:Human
宿主:Mouse验证实验:ELISA, WB, IHC
克隆性:monoclonal亚型:IgG2b
¥1900
规格:
货期: 三个工作日+顺丰&京东快递时长
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产品名称
VEGF antibody
货号
FNab09933
规格
100μg
状态
liquid
纯化方法
protein A+G purified
纯度
≥95% as determined by SDS-PAGE
克隆性
monoclonal
亚型
IgG2b
Clone ID
5H5
存储
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
免疫原信息
免疫原
vascular endothelial growth factor A
别称
L VEGFA antibody, MVCD1 antibody, Vascular permeability factor antibody, VEGF antibody, VEGF A antibody, VEGFA antibody, VPF antibody
UniProt ID
P15692
分子量
45 kDa
验证实验
验证实验
ELISA, WB, IHC
建议稀释比例
WB: 1:1000-1:4000; IHC: 1:50-1:500
验证图片
MCF-7 cells were subjected to SDS PAGE followed by western blot with FNab09933 (VEGF antibody) at dilution of 1:2000
Immunohistochemistry of paraffin-embedded human stomach cancer tissue slide using FNab09933 (VEGF antibody) at dilution of 1:200
背景介绍
VEGFA, also named as VEGF or VPF, belongs to the PDGF/VEGF growth factor family. It is a growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. VEGFA induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. It binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. Defects in VEGFA are a cause of susceptibility to microvascular complications of diabetes type 1(MVCD1). VEGFA has 13 isoforms with MW 16kd to 45kd. Some isoforms has homodimer form, such as VEGFA189(38kd), VEFGA110(34kd). VEGFA is a 34kd to 42kd, dimeric, disulfide-bound glycoprotein. VEGF-A exists in at least seven homodimeric isoforms. The monomers consist of 121, 145, 148, 165, 183, 189, or 206 amino acids(PMID:15602010). This antibody can recognize all the isoforms of VEFGA.