产品
本公司产品仅供体外研究使用，不用于临床诊断
TRADD antibody
¥1500
规格：
货期：
三个工作日+顺丰&京东快递时长
- 产品名称
- TRADD antibody
- 货号
- FNab10260
- 规格
- 100μg
- 状态
- liquid
- 纯化方法
- Immunogen affinity purified
- 纯度
- ≥95% as determined by SDS-PAGE
- 克隆性
- polyclonal
- 亚型
- IgG
- 存储
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
免疫原信息
- 免疫原
- TNFRSF1A-associated via death domain
- 别称
- Hs.89862 antibody, TRADD antibody
- UniProt ID
- Q15628
- 分子量
- 34 kDa, 27 kDa
验证实验
- 验证实验
- ELISA, WB, IHC
- 建议稀释比例
- WB: 1:200 - 1:2000; IHC: 1:50 - 1:500
验证图片
Jurkat cells were subjected to SDS PAGE followed by western blot with FNab10260( TRADD Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded mouse heart tissue slide using FNab10260( TRADD antibody at dilution of 1:200
- 背景介绍
- The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A(By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.
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