产品
本公司产品仅供体外研究使用，不用于临床诊断
Cyclin D1 antibody
¥1500
规格：
货期：
三个工作日+顺丰&京东快递时长
- 产品名称
- Cyclin D1 antibody
- 货号
- FNab10467
- 规格
- 100μg
- 状态
- liquid
- 纯化方法
- Immunogen affinity purified
- 纯度
- ≥95% as determined by SDS-PAGE
- 克隆性
- polyclonal
- 亚型
- IgG
- 存储
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
免疫原信息
- 免疫原
- cyclin D1
- 别称
- B cell lymphoma 1 protein antibody, CCND1 antibody, cyclin D1 antibody, D11S287E antibody, G1/S specific cyclin D1 antibody, PRAD1 antibody, PRAD1 oncogene antibody, U21B31 antibody
- UniProt ID
- P24385
- 分子量
- 36 kDa
验证实验
- 验证实验
- ELISA, WB, IHC
- 建议稀释比例
- WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
验证图片
various lysates were subjected to SDS PAGE followed by western blot with FNab10467(Cyclin D1 Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human esophagus using FNab10467(cyclin D1 antibody) at dilution of 1:100
- 背景介绍
- CCND1(cyclin D1), also known as PRAD1 or BCL1, belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. CCND1 forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. The CCND1 gene, located on 11q13 has been reported to be overexpressed in mantle cell lymphoma(MCL) due to the chromosomal translocation. CCND1 has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Over-expression of CCND1 is known to correlate with the early onset of cancer and risk of tumor progression and metastasis.
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