产品
本公司产品仅供体外研究使用，不用于临床诊断
KLRK1 antibody
¥1900
规格：
货期：
三个工作日+顺丰&京东快递时长
- 产品名称
- KLRK1 antibody
- 货号
- FNab10477
- 规格
- 100μg
- 状态
- liquid
- 纯化方法
- Immunogen affinity purified
- 纯度
- ≥95% as determined by SDS-PAGE
- 克隆性
- polyclonal
- 亚型
- IgG
- 存储
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
免疫原信息
- 免疫原
- NKG2-D type II integral membrane protein
- 别称
- KLRK1 antibody, CD314 antibody, D12S2489E antibody, KLR antibody, NKG2-D antibody, NKG2D antibody
- UniProt ID
- P26718
- 分子量
- 30 kDa
验证实验
- 验证实验
- ELISA, WB
- 建议稀释比例
- WB: 1:500-1:2000
验证图片
HepG2 cells were subjected to SDS PAGE followed by western blot with FNab10477(KLRK1 Antibody) at dilution of 1:1000
- 背景介绍
- Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster.
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