生长因子有多种，如血小板类生长因子（血小板来源生长因子，PDGF；骨肉瘤来源生长因子ODGF）、表皮生长因子类（表皮生长因子EGF、转化生长因子TGFα和TGFβ）、成纤维细胞生长因子（αFGF、βFGF）、类胰岛素生长因子（IGF-Ⅰ、IGF-Ⅱ）、神经生长因子（NGF）、白细胞介素类生长因子（IL-1、IL-1、IL-3等）、红细胞生长素（EPO）、集落刺激因子（CSF）等。由于生长因子是由正常细胞分泌，既无药物类毒性，也无免疫反应，因此在研究其生理作用机制同时，有的已试用于临床治疗。如白细胞介素-2已用于治疗癌症，对肾癌、黑色素瘤效果明显；也用于免疫调节剂和自家免疫有关的疾病。白细胞介素-3用于治疗骨髓功能衰竭与血小板缺失等适应症。表皮生长因子用于人烧伤、创伤、糖尿病皮肤溃疡、褥疮、静脉曲张性皮肤溃疡和角膜损伤，可促进伤口愈合。
生长因子
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表皮生长因子（EGF）是一种由53个氨基酸残基组成的耐热单链低分子多肽。EGF与靶细胞上的EGF受体特异性识别结合后，发生一系列生化反应，最终可促进靶细胞的DNA合成及有丝分裂。EGF无糖基部位，非常稳定，耐热耐酸，广泛存在于体液和多种腺体中，主要由颌下腺、十二指肠合成，在人体的绝大多数体液中均已发现，在乳汁、尿液、精液中的含量特异性地增高，但在血清中的浓度较低。EGF作用广泛，对估计肿瘤预后，选择治疗方案以及胃溃疡、肝功能衰竭等治疗上均有重要意义。
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种属 |
货号 |
产品名称 |
灵敏度 |
检测范围 |
目录价 96T |
|
Human |
EH0009 |
2.344pg/ml |
3.906-250pg/ml |
¥2,480 |
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Rat |
ER0018 |
2.344pg/ml |
3.906-250pg/ml |
¥2,480 |
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|
Mouse |
EM0007 |
9.375pg/ml |
15.625-1000pg/ml |
¥2,480 |
成纤维细胞生长因子（fibroblast growth factor,FGF）有几种异构体，在动脉硬化灶中起作用的主要是bFGF（basic fibroblast growth factor），bFGF可以由内皮细胞、平滑肌细胞、巨噬细胞分泌。它的作用是促进内皮细胞的游走和平滑肌细胞的增殖，不能使平滑肌细胞游走。能够促进新血管形成，修复损害的内皮细胞。FGF被认为是病灶形成促进因子，但从修复角度看它也有有利的一面。
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种属 |
货号 |
产品名称 |
灵敏度 |
检测范围 |
目录价 96T |
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Rat |
ER0022 |
9.375pg/ml |
15.625-1000pg/ml |
¥2,480 |
|
|
Human |
EH0501 |
18.75pg/ml |
31.25-2000pg/ml |
¥2,480 |
|
|
Mouse |
EM0078 |
18.75pg/ml |
31.25-2000pg/ml |
¥2,480 |
|
|
Rat |
ER0948 |
9.375pg/ml |
15.625-1000pg/ml |
¥2,480 |
|
|
Human |
EH1979 |
4.688pg/ml |
7.813-500pg/ml |
¥2,480 |
|
|
Mouse |
EM0692 |
0.094ng/ml |
0.156-10ng/ml |
¥2,480 |
|
|
Mouse |
EM0286 |
2.813pg/ml |
4.688-300pg/ml |
¥2,480 |
|
|
Human |
EH8505 |
0.938pg/ml |
1.563-100pg/ml |
¥2,480 |
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Rat |
ER2031 |
9.375pg/ml |
15.625-1000pg/ml |
¥2,480 |
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|
Rat |
ER0949 |
9.375pg/ml |
15.625-1000pg/ml |
¥2,480 |
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Human |
EH0129 |
9.375pg/ml |
15.625-1000pg/ml |
¥2,480 |
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|
Rat |
ER0764 |
9.375pg/ml |
15.625-1000pg/ml |
¥2,480 |
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Human |
EH0541 |
7.5pg/ml |
12.5-800pg/ml |
¥2,480 |
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Mouse |
EM0869 |
7.5pg/ml |
12.5-800pg/ml |
¥2,480 |
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Human |
EH2502 |
9.375pg/ml |
15.625-1000pg/ml |
¥2,480 |
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Rat |
ER0950 |
18.75pg/ml |
31.25-2000pg/ml |
¥2,480 |
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Human |
EH0130 |
9.375pg/ml |
15.625-1000pg/ml |
¥2,480 |
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|
Mouse |
EM0254 |
18.75pg/ml |
31.25-2000pg/ml |
¥2,480 |
|
|
Human |
EH14500 |
9.375pg/ml |
15.625-1000pg/ml |
¥2,480 |
|
|
Rat |
ER0147 |
9.375pg/ml |
15.625-1000pg/ml |
¥2,480 |
|
|
Human |
EH3058 |
9.375pg/ml |
15.625-1000pg/ml |
¥2,480 |
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Mouse |
EM0271 |
9.375pg/ml |
15.625-1000pg/ml |
¥2,480 |
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Rat |
ER0951 |
9.375pg/ml |
15.625-1000pg/ml |
¥2,480 |
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Human |
EH0131 |
37.5pg/ml |
62.5-4000pg/ml |
¥2,480 |
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Human |
EH0883 |
46.875pg/ml |
78.125-5000pg/ml |
¥2,480 |
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Rat |
ER0952 |
9.375pg/ml |
15.625-1000pg/ml |
¥2,480 |
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Human |
EH0710 |
56.25pg/ml |
93.75-6000pg/ml |
¥2,480 |
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Mouse |
EM1022 |
9.375pg/ml |
15.625-1000pg/ml |
¥2,480 |
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Rat |
ER0173 |
9.375pg/ml |
15.625-1000pg/ml |
¥2,480 |
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Human |
EH0132 |
18.75pg/ml |
31.25-2000pg/ml |
¥2,480 |
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Mouse |
EM1023 |
9.375pg/ml |
15.625-1000pg/ml |
¥2,480 |
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Human |
EH2123 |
7.5pg/ml |
12.5-800pg/ml |
¥2,480 |
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Rat |
ER0224 |
37.5pg/ml |
62.5-4000pg/ml |
¥2,480 |
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Human |
EH0133 |
37.5pg/ml |
62.5-4000pg/ml |
¥2,480 |
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Mouse |
EM0330 |
37.5pg/ml |
62.5-4000pg/ml |
¥2,480 |
血小板衍生生长因子PDGF于1974年发现的一种刺激结缔组织等组织细胞增长的肽类调节因子，因其来源于血小板而得名，正常生理状态下存在于血小板的α颗粒内，当血液凝固时由崩解的血小板释放出来并且被激活，具有刺激特定细胞趋化与促进特定细胞生长的生物活性。此外，在组织受到损伤时巨噬细胞、血管平滑肌细胞、成纤维细胞、内皮细胞、胚胎干细胞等也可以合成并释放PDGF。肝脏受损时，巨噬细胞、血小板、浸润的炎细胞、受损的内皮细胞及激活的肝星形细胞均可以分泌PDGF。以自分泌、旁分泌的方式发挥作用。结合的PDGF是分子量为30KD的热稳定糖蛋白，是靠二硫键相连的A、B两条多肽链组合成的二聚体。
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种属 |
货号 |
产品名称 |
灵敏度 |
检测范围 |
目录价 96T |
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Rat |
ER1240 |
0.094ng/ml |
0.156-10ng/ml |
¥2,480 |
|
|
Human |
EH3531 |
18.75pg/ml |
31.25-2000pg/ml |
¥2,480 |
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|
Mouse |
EM1268 |
18.75pg/ml |
31.25-2000pg/ml |
¥2,480 |
|
|
Rat |
ER1241 |
9.375pg/ml |
15.625-1000pg/ml |
¥2,480 |
|
|
Human |
EH0511 |
9.375pg/ml |
15.625-1000pg/ml |
¥2,480 |
|
|
Human |
EH3532 |
9.375pg/ml |
15.625-1000pg/ml |
¥2,480 |
|
|
Rat |
ER0056 |
4.688pg/ml |
7.813-500pg/ml |
¥2,480 |
|
|
Human |
EH0139 |
9.375pg/ml |
15.625-1000pg/ml |
¥2,480 |
|
|
Rat |
ER0145 |
18.75pg/ml |
31.25-2000pg/ml |
¥2,480 |
|
|
Human |
EH0548 |
9.375pg/ml |
15.625-1000pg/ml |
¥2,480 |
|
|
Mouse |
EM0269 |
18.75pg/ml |
31.25-2000pg/ml |
¥2,480 |
|
|
Rat |
ER1242 |
18.75pg/ml |
31.25-2000pg/ml |
¥2,480 |
|
|
Human |
EH0254 |
18.75pg/ml |
31.25-2000pg/ml |
¥2,480 |
|
|
Mouse |
EM1269 |
0.094ng/ml |
0.156-10ng/ml |
¥2,480 |
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|
Rat |
ER0312 |
9.375pg/ml |
15.625-1000pg/ml |
¥2,480 |
|
|
Human |
EH0536 |
37.5pg/ml |
62.5-4000pg/ml |
¥2,480 |
|
|
Mouse |
EM1270 |
18.75pg/ml |
31.25-2000pg/ml |
¥2,480 |
|
|
Rat |
ER1244 |
0.188ng/ml |
0.313-20ng/ml |
¥2,480 |
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|
Human |
EH0612 |
7.5pg/ml |
12.5-800pg/ml |
¥2,480 |
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Mouse |
EM1271 |
9.375pg/ml |
15.625-1000pg/ml |
¥2,480 |
血管内皮生长因子（vascular endothelial growth factor，VEGF）是一种高度特异性的促血管内皮细胞生长因子，具有促进血管通透性增加、细胞外基质变性、血管内皮细胞迁移、增殖和血管形成等作用。血管内皮生长因子通常是指人体生理的一种糖蛋白。当人体受到脑外伤，因此在外伤愈合过程中，血管内皮生长因子表达增加，就可以促进组织的愈合和生长。
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种属 |
货号 |
产品名称 |
灵敏度 |
检测范围 |
目录价 96T |
|
Human |
EH0327 |
18.75pg/ml |
31.25-2000pg/ml |
¥2,480 |
|
|
Mouse |
EM0205 |
9.375pg/ml |
15.625-1000pg/ml |
¥2,480 |
|
|
Rat |
ER0069 |
18.75pg/ml |
31.25-2000pg/ml |
¥2,480 |
|
|
Human |
EH3950 |
18.75pg/ml |
31.25-2000pg/ml |
¥2,480 |
|
|
Human |
EH3952 |
9.375pg/ml |
15.625-1000pg/ml |
¥2,480 |
|
|
Mouse |
EM0216 |
9.375pg/ml |
15.625-1000pg/ml |
¥2,480 |
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|
Rat |
ER0085 |
9.375pg/ml |
15.625-1000pg/ml |
¥2,480 |
|
|
Human |
EH0328 |
0.188ng/ml |
0.313-20ng/ml |
¥2,480 |
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|
Mouse |
EM0217 |
18.75pg/ml |
31.25-2000pg/ml |
¥2,480 |
|
|
Rat |
ER1424 |
4.688pg/ml |
7.813-500pg/ml |
¥2,480 |
|
|
Human |
EH3953 |
37.5pg/ml |
62.5-4000pg/ml |
¥2,480 |
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|
Mouse |
EM1444 |
18.75pg/ml |
31.25-2000pg/ml |
¥2,480 |
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|
Rat |
ER1425 |
9.375pg/ml |
15.625-1000pg/ml |
¥2,480 |
转化生长因子(TGF)是指两类多肽类生长因子,转化生长因子-α和转化生长因子-β。转化生长因子-α是由巨噬细胞,脑细胞和表皮细胞产生,可诱导上皮发育。人类转化生长因子－β有三个亚型,TGF-β1,TGF-β2,TGF-β3。转化生长因子-β (Transforming growth factor beta, TGF-β)是一多功能蛋白质，可以影响多种细胞的生长，分化、细胞凋亡及免疫调节等功能。转化生长因子-β属于转化生长因子-β超家族蛋白。转化生长因子-β可以结合到细胞表面的转化生长因子-β受体结合而激活其受体。转化生长因子-β受体是丝氨酸/苏氨酸激酶受体。其信号传递可以通过SMAD信号通路和/或DAXX信号通路。
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种属 |
货号 |
产品名称 |
灵敏度 |
检测范围 |
目录价 96T |
|
Mouse |
EM1405 |
9.375pg/ml |
15.625-1000pg/ml |
¥2,480 |
|
|
Human |
EH0284 |
9.375pg/ml |
15.625-1000pg/ml |
¥2,480 |
|
|
Rat |
ER0126 |
9.375pg/ml |
15.625-1000pg/ml |
¥2,480 |
|
|
Human |
EH0287 |
18.75pg/ml |
31.25-2000pg/ml |
¥2,480 |
|
|
Mouse |
EM0176 |
18.75pg/ml |
31.25-2000pg/ml |
¥2,480 |
|
|
Rat |
ER1378 |
18.75pg/ml |
31.25-2000pg/ml |
¥2,480 |
|
|
Human |
EH0288 |
9.375pg/ml |
15.625-1000pg/ml |
¥2,480 |
|
|
Mouse |
EM0177 |
9.375pg/ml |
15.625-1000pg/ml |
¥2,480 |
|
|
Rat |
ER0062 |
9.375pg/ml |
15.625-1000pg/ml |
¥2,480 |
|
|
Human |
EH0289 |
9.375pg/ml |
15.625-1000pg/ml |
¥2,480 |
|
|
Mouse |
EM0178 |
9.375pg/ml |
15.625-1000pg/ml |
¥2,480 |
|
|
Rat |
ER0063 |
9.375pg/ml |
15.625-1000pg/ml |
¥2,480 |
引用文献
Angewandte Chemie IF: 12.9590
Engineering a Second-Order DNA Logic-Gated Nanorobot to Sense and Release on Live Cell Membranes for Multiplexed Diagnosis and Synergistic Therapy- 货号
- 产品名称
- EH0254
- Human PDGF-BB(Platelet Derived Growth Factor-BB) ELISA Kit