产品
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ATG12 antibody
¥1900
规格：
货期：
三个工作日+顺丰快递时长
- 产品名称
- ATG12 antibody
- 货号
- FNab00666
- 规格
- 100μg
- 状态
- liquid
- 纯化方法
- Immunogen affinity purified
- 纯度
- ≥95% as determined by SDS-PAGE
- 克隆性
- polyclonal
- 亚型
- IgG
- 存储
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
免疫原信息
- 免疫原
- ATG12 autophagy related 12 homolog
- 别称
- APG12 antibody, APG12L antibody
- UniProt ID
- O94817
- 分子量
- 48-50kd
验证实验
- 验证实验
- ELISA, WB, IHC, IP
- 建议稀释比例
- WB: 1:500-1:2000; IP: 1:500-1:2000 ; IHC: 1:20-1:200
验证图片
human bladder tissue were subjected to SDS PAGE followed by western blot with FNab00666(ATG12 antibody) at dilution of 1:500
IP Result of anti-ATG12 (IP:FNab00666, 4ug; Detection:FNab00666 1:300) with HEK-293 cells lysate 880ug.
Immunohistochemistry of paraffin-embedded human prostate cancer using FNab00666(ATG12 antibody) at dilution of 1:50
- 背景介绍
- Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Plays also a role in translation or delivery of incoming viral RNA to the translation apparatus.
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