产品
本公司产品仅供体外研究使用，不用于临床诊断
Beclin 1 antibody
¥1900
规格：
货期：
三个工作日+顺丰快递时长
- 产品名称
- Beclin 1 antibody
- 货号
- FNab00860
- 规格
- 100μg
- 状态
- liquid
- 纯化方法
- Immunogen affinity purified
- 纯度
- ≥95% as determined by SDS-PAGE
- 克隆性
- polyclonal
- 亚型
- IgG
- 存储
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
免疫原信息
- 免疫原
- beclin 1, autophagy related
- 别称
- ATG6 antibody, Beclin 1 antibody, beclin 1 antibody, autophagy related antibody, beclin1 antibody, BECN1 antibody, GT197 antibody, Protein GT197 antibody, VPS30 antibody
- UniProt ID
- Q14457
- 分子量
- 60 kDa
验证实验
- 验证实验
- ELISA, IHC, WB,IF
- 建议稀释比例
- WB: 1:500-1:5000; IHC: 1:20-1:200; IF: 1:20-1:200
验证图片
MDA-MB-453s cells were subjected to SDS PAGE followed by western blot with FNab00860(Beclin 1 Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human colon cancer using FNab00860(Beclin 1 antibody) at dilution of 1:50
Immunofluorescent analysis of NIH/3T3 cells using Beclin 1 Antibody at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IgG(H+L)
- 背景介绍
- Beclin-1(BECN1), also known as ATG6 or VPS30, has a central role in autophagy, a process of programmed cell survival, which is increased during periods of cell stress and extinguished during the cell cycle. Beclin-1, may play a role in antiviral host defense. It protects against infection by a neurovirulent strain of Sindbis virus. Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration. A progressively reduced Beclin-1 expression is reported to correlate with the primary tumor growth of squamous cell carcinoma and adenocarcinoma of the lung. Caspase-mediated cleavage of Beclin 1 promotes crosstalk between apoptosis and autophagy.
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