产品
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AFF1 antibody
¥1750
规格：
货期：
三个工作日+顺丰快递时长
- 产品名称
- AFF1 antibody
- 货号
- FNab00195
- 规格
- 100μg
- 状态
- liquid
- 纯化方法
- Immunogen affinity purified
- 纯度
- ≥95% as determined by SDS-PAGE
- 克隆性
- polyclonal
- 亚型
- IgG
- 存储
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
免疫原信息
- 免疫原
- AF4/FMR2 family, member 1
- 别称
- AFF1 antibody, MLLT2 antibody, AF4 MLL antibody, PBM1 antibody, AF 4 antibody
- UniProt ID
- P51825
- 分子量
- 131 kDa
验证实验
- 验证实验
- ELISA, WB, IHC, IF
- 建议稀释比例
- WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:100
验证图片
K-562 cells were subjected to SDS PAGE followed by western blot with FNab00195(AFF1-Specific antibody) at dilution of 1:1000
Immunofluorescence analysis of U2OS cells using FNab00195(AFF1-Specific antibody).
- 背景介绍
- This gene encodes a member of the AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome family of proteins, which have been implicated in childhood lymphoblastic leukemia, Fragile X E site mental retardation, and ataxia. It is the prevalent mixed-lineage leukemia fusion gene associated with spontaneous acute lymphoblastic leukemia. Members of this family have three conserved domains: an N-terminal homology domain, an AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome domain, and a C-terminal homology domain. The protein functions as a regulator of RNA polymerase II-mediated transcription through elongation and chromatin remodeling functions. Through RNA interference screens, this gene has been shown to promote the expression of CD133, a plasma membrane glycoprotein required for leukemia cell survival. Alternative splicing results in multiple transcript variants.
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