产品
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Aminoacylase 1 antibody
¥1750
规格：
货期：
三个工作日+顺丰快递时长
- 产品名称
- Aminoacylase 1 antibody
- 货号
- FNab00362
- 规格
- 100μg
- 状态
- liquid
- 纯化方法
- Immunogen affinity purified
- 纯度
- ≥95% as determined by SDS-PAGE
- 克隆性
- polyclonal
- 亚型
- IgG
- 存储
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
免疫原信息
- 免疫原
- aminoacylase 1
- 别称
- ACY 1 antibody, ACY1 antibody, ACY1D antibody, ACYLASE antibody, Aminoacylase 1 antibody
- UniProt ID
- Q03154
- 分子量
- 46 kDa
验证实验
- 验证实验
- ELISA, WB, IHC, IF
- 建议稀释比例
- WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200
验证图片
K-562 cells were subjected to SDS PAGE followed by western blot with FNab00362( ACY1 Antibody) at dilution of 1:600
Immunohistochemistry of paraffin-embedded human esophageal cancer using FNab00362( ACY1 Antibody) at dilution of 1:50
- 背景介绍
- This gene encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene, as represented in GeneID:100526760. A related pseudogene has been identified on chromosome 18.
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