产品
本公司产品仅供体外研究使用，不用于临床诊断
AMPK beta 1 antibody
¥1500
规格：
货期：
三个工作日+顺丰快递时长
- 产品名称
- AMPK beta 1 antibody
- 货号
- FNab00377
- 规格
- 100μg
- 状态
- liquid
- 纯化方法
- Immunogen affinity purified
- 纯度
- ≥95% as determined by SDS-PAGE
- 克隆性
- polyclonal
- 亚型
- IgG
- 存储
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
免疫原信息
- 免疫原
- protein kinase, AMP-activated, beta 1 non-catalytic subunit
- 别称
- AMPK antibody, AMPK beta 1 antibody, AMPK subunit beta 1 antibody, AMPKb antibody, HAMPKb antibody, PRKAB1 antibody
- UniProt ID
- Q9Y478
- 分子量
- 37 kDa
验证实验
- 验证实验
- ELISA, WB, IHC
- 建议稀释比例
- WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
验证图片
mouse liver tissue were subjected to SDS PAGE followed by western blot with FNab00377( PRKAB1 Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded rat kidney using FNab00377(PRKAB1 antibody) at dilution of 1:100
- 背景介绍
- The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex.
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