产品
本公司产品仅供体外研究使用，不用于临床诊断
AMPK beta 2 antibody
¥1500
规格：
货期：
三个工作日+顺丰快递时长
- 产品名称
- AMPK beta 2 antibody
- 货号
- FNab00378
- 规格
- 100μg
- 状态
- liquid
- 纯化方法
- Immunogen affinity purified
- 纯度
- ≥95% as determined by SDS-PAGE
- 克隆性
- polyclonal
- 亚型
- IgG
- 存储
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
免疫原信息
- 免疫原
- protein kinase, AMP-activated, beta 2 non-catalytic subunit
- 别称
- AMPK beta 2 antibody, AMPK subunit beta 2 antibody, PRKAB2 antibody
- UniProt ID
- O43741
- 分子量
- 35 kDa
验证实验
- 验证实验
- ELISA, WB, IHC
- 建议稀释比例
- WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
验证图片
human brain tissue were subjected to SDS PAGE followed by western blot with FNab00378(PRKAB2 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded rat kidney using FNab00378(PRKAB2 antibody) at dilution of 1:100
- 背景介绍
- The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been found for this gene.
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