产品
本公司产品仅供体外研究使用，不用于临床诊断
androgen receptor antibody
¥1750
规格：
货期：
三个工作日+顺丰快递时长
- 产品名称
- androgen receptor antibody
- 货号
- FNab00388
- 规格
- 100μg
- 状态
- liquid
- 纯化方法
- Immunogen affinity purified
- 纯度
- ≥95% as determined by SDS-PAGE
- 克隆性
- polyclonal
- 亚型
- IgG
- 存储
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
免疫原信息
- 免疫原
- androgen receptor
- 别称
- AIS antibody, androgen receptor antibody, AR antibody, DHTR antibody, Dihydrotestosterone receptor antibody, HUMARA antibody, HYSP1 antibody, KD antibody, NR3C4 antibody, SBMA antibody, SMAX1 antibody, TFM antibody
- UniProt ID
- P10275
- 分子量
- 100 kDa
验证实验
- 验证实验
- ELISA, WB, IHC
- 建议稀释比例
- WB: 1:500 - 1:2000; IHC: 1:50 - 1:100
验证图片
22RV1 cells were subjected to SDS PAGE followed by western blot with FNab00388(AR antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded mouse brain tissue slide using FNab00388( AR Antibody) at dilution of 1:50.
- 背景介绍
- The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (SBMA, also known as Kennedy's disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Alternative splicing results in multiple transcript variants encoding different isoforms.
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