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BIN1 antibody

分类：

研究方向：

说明书 MSDS

¥1750

规格：

货期：三个工作日+顺丰快递时长

产品名称: BIN1 antibody
货号: FNab00897
规格: 100μg
状态: liquid
纯化方法: Immunogen affinity purified
纯度: ≥95% as determined by SDS-PAGE
克隆性: polyclonal
亚型: IgG
存储: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

免疫原信息

验证实验

验证图片

Jurkat cells were subjected to SDS PAGE followed by western blot with FNab00897(BIN1 antibody) at dilution of 1:1000

Immunohistochemistry of paraffin-embedded human kidney using FNab00897(BIN1 antibody) at dilution of 1:100

背景介绍: This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in several transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.