产品
本公司产品仅供体外研究使用，不用于临床诊断
GSTA2 antibody
¥1750
规格：
货期：
三个工作日+顺丰快递时长
- 产品名称
- GSTA2 antibody
- 货号
- FNab03687
- 规格
- 100μg
- 状态
- liquid
- 纯化方法
- Immunogen affinity purified
- 纯度
- ≥95% as determined by SDS-PAGE
- 克隆性
- polyclonal
- 亚型
- IgG
- 存储
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
免疫原信息
- 免疫原
- glutathione S-transferase alpha 2
- 别称
- Glutathione S transferase A2 antibody, GST class alpha member 2 antibody, GST gamma antibody, GST HA subunit 2 antibody, GST2 antibody, GSTA2 antibody, GSTA2 2 antibody, GTA2 antibody, GTH2 antibody
- UniProt ID
- P09210
- 分子量
- 25 kDa
验证实验
- 验证实验
- ELISA, WB, IHC
- 建议稀释比例
- WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
验证图片
HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab03687(GSTA2 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human prostate cancer using FNab03687(GSTA2 antibody) at dilution of 1:100
- 背景介绍
- Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti- cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation.
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