HeLa cells were subjected to SDS PAGE followed by western blot with FNab03765( HAX1 Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded mouse heart using FNab03765(HAX1 antibody) at dilution of 1:50
Immunofluorescence analysis of A549 cells using FNab03765(HAX1 antibody). Blue: DAPI for nuclear staining.
背景介绍
The protein encoded by this gene is known to associate with hematopoietic cell-specific Lyn substrate 1, a substrate of Src family tyrosine kinases. It also interacts with the product of the polycystic kidney disease 2 gene, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with the F-actin-binding protein, cortactin. It was earlier thought that this gene product is mainly localized in the mitochondria, however, recent studies indicate it to be localized in the cell body. Mutations in this gene result in autosomal recessive severe congenital neutropenia, also known as Kostmann disease. Two transcript variants encoding different isoforms have been found for this gene.