产品
本公司产品仅供体外研究使用，不用于临床诊断
HDAC1 antibody
¥2100
规格：
货期：
三个工作日+顺丰快递时长
- 产品名称
- HDAC1 antibody
- 货号
- FNab03793
- 规格
- 100μg
- 状态
- liquid
- 纯化方法
- Protein A+G purification
- 纯度
- ≥95% as determined by SDS-PAGE
- 克隆性
- monoclonal
- 亚型
- IgG2a
- Clone ID
- 9H10
- 存储
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
免疫原信息
- 免疫原
- histone deacetylase 1
- 别称
- DKFZp686H12203 antibody, GON 10 antibody, HD1 antibody, HDAC1 antibody, histone deacetylase 1 antibody, RPD3 antibody, RPD3L1 antibody
- UniProt ID
- Q13547
- 分子量
- 60 kDa
验证实验
- 验证实验
- ELISA, WB, IHC, IF
- 建议稀释比例
- WB: 1:10000 - 1:50000; IHC: 1:100 - 1:200; IF: 1:50 - 1:200
验证图片
HepG2 cells were subjected to SDS PAGE followed by western blot with FNab03793(HDAC1 antibody) at dilution of 1:30000
Immunohistochemistry of paraffin-embedded human lung cancer using FNab03793(HDAC1 antibody) at dilution of 1:200
- 背景介绍
- Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones(H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase(HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation.
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