产品
本公司产品仅供体外研究使用，不用于临床诊断
TRIM63 antibody
¥1900
规格：
货期：
三个工作日+顺丰快递时长
- 产品名称
- TRIM63 antibody
- 货号
- FNab08992
- 规格
- 100μg
- 状态
- liquid
- 纯化方法
- Immunogen affinity purified
- 纯度
- ≥95% as determined by SDS-PAGE
- 克隆性
- polyclonal
- 亚型
- IgG
- 存储
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
免疫原信息
- 免疫原
- tripartite motif-containing 63
- 别称
- FLJ32380 antibody, IRF antibody, Iris RING finger protein antibody, MuRF 1 antibody, MURF1 antibody, MURF2 antibody, RING finger protein 28 antibody, RNF28 antibody, SMRZ antibody, TRIM63 antibody, tripartite motif containing 63 antibody
- UniProt ID
- Q969Q1
- 分子量
- 40 kDa
验证实验
- 验证实验
- ELISA, WB, IHC, IF
- 建议稀释比例
- WB: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:10-1:100
验证图片
mouse heart tissue were subjected to SDS PAGE followed by western blot with FNab08992(TRIM63 antibody) at dilution of 1:300
Immunohistochemistry of paraffin-embedded human heart using FNab08992(TRIM63 antibody) at dilution of 1:50
Immunofluorescent analysis of HeLa cells using FNab08992 (TRIM63 antibody) at dilution of 1:25 and Rhodamine-Goat anti-Rabbit IgG
- 背景介绍
- E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.
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