产品
本公司产品仅供体外研究使用，不用于临床诊断
TSPAN12 antibody
¥1900
规格：
货期：
三个工作日+顺丰&京东快递时长
- 产品名称
- TSPAN12 antibody
- 货号
- FNab09055
- 规格
- 100μg
- 状态
- liquid
- 纯化方法
- Immunogen affinity purified
- 纯度
- ≥95% as determined by SDS-PAGE
- 克隆性
- polyclonal
- 亚型
- IgG
- 存储
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
免疫原信息
- 免疫原
- tetraspanin 12
- 别称
- NET 2 antibody, NET2 antibody, Tetraspan NET 2 antibody, tetraspanin 12 antibody, TM4SF12 antibody, Tspan 12 antibody, TSPAN12 antibody
- UniProt ID
- O95859
- 分子量
- 28 kDa
验证实验
- 验证实验
- ELISA, WB
- 建议稀释比例
- WB: 1:200-1:2000
验证图片
HepG2 cells were subjected to SDS PAGE followed by western blot with FNab09055(TSPAN12 antibody) at dilution of 1:500
- 背景介绍
- Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin(NDP) signal transduction. Acts in concert with norrin(NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin(CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin(NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin(CTNNB1)(By similarity). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein(APP). Activates MMP14/MT1-MMP-dependent cleavage activity.
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