产品
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Tuberin-Specific antibody
¥1900
规格：
货期：
三个工作日+顺丰&京东快递时长
- 产品名称
- Tuberin-Specific antibody
- 货号
- FNab09101
- 规格
- 100μg
- 状态
- liquid
- 纯化方法
- Immunogen affinity purified
- 纯度
- ≥95% as determined by SDS-PAGE
- 克隆性
- polyclonal
- 亚型
- IgG
- 存储
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
免疫原信息
- 免疫原
- tuberous sclerosis 2
- 别称
- FLJ43106 antibody, LAM antibody, TSC2 antibody, TSC4 antibody, Tuberin antibody, tuberous sclerosis 2 antibody, Tuberous sclerosis 2 protein antibody
- UniProt ID
- P49815
- 分子量
- 200 kDa
验证实验
- 验证实验
- ELISA, WB, IF, IHC
- 建议稀释比例
- WB: 1:200-1:2000; IHC: 1:20-1:200；IF: 1:10-1:100
验证图片
mouse lung tissue were subjected to SDS PAGE followed by western blot with FNab09101(TSC2-Specific antibody) at dilution of 1:300
Immunohistochemistry of paraffin-embedded human kidney slide using FNab09101(TSC2-Specific Antibody) at dilution of 1:50
- 背景介绍
- TSC2, also named as TSC4, FLJ43106 and LAM, acts as a GTPase-activating protein(GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. In complex with TSC1, TSC2 inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. TSC2 implicated as a tumor suppressor. It is involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. TSC2 stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors. Mutations in either TSC2 or the related TSC1(hamartin) gene cause tuberous sclerosis complex(TSC), an autosomal dominant disorder characterized by development of multiple, widespread non-malignant tumors. The antibody is specific to TSC2.
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