产品
本公司产品仅供体外研究使用，不用于临床诊断
uPAR antibody
¥1900
规格：
货期：
三个工作日+顺丰&京东快递时长
- 产品名称
- uPAR antibody
- 货号
- FNab09268
- 规格
- 100μg
- 状态
- liquid
- 纯化方法
- Immunogen affinity purified
- 纯度
- ≥95% as determined by SDS-PAGE
- 克隆性
- polyclonal
- 亚型
- IgG
- 存储
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
免疫原信息
- 免疫原
- plasminogen activator, urokinase receptor
- 别称
- CD87 antibody, MO3 antibody, PLAUR antibody, U PAR antibody, UPAR antibody, URKR antibody
- UniProt ID
- Q03405
- 分子量
- 37-70 kDa
验证实验
- 验证实验
- ELISA, WB, IP
- 建议稀释比例
- WB: 1:200-1:2000; IP: 1:200-1:1000
验证图片
RAW264.7 cells were subjected to SDS PAGE followed by western blot with FNab09268(uPAR, PLAUR antibody) at dilution of 1:500
IP Result of anti-uPAR, PLAUR (IP:FNab09268, 4ug; Detection:FNab09268 1:300) with RAW 264.7 cells lysate 4000ug.
- 背景介绍
- Urokinase plasminogen activator surface receptor(uPAR, also known as PLAUR or CD87) is a 45-65 kDa, highly glycosylated, GPI-anchored membrane protein. It contains three homologous domains(D1-D3) of which the N-terminal one(D1) represents the uPA-binding domain. After binding to uPAR, urokinase plasminogen activator(uPA) cleaves plasminogen, generating the active protease plasmin which is involved in a wide variety of physiologic and pathologic processes. In addition to regulating proteolysis, uPAR has important function in cell adhesion, migration and proliferation. Studies reveal that uPAR expression is elevated during inflammation and tissue remodelling and in many human cancers, in which it frequently indicates poor prognosis.(PMID 20027185; 12461559)
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