产品
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USP15 antibody
¥1900
规格：
货期：
三个工作日+顺丰快递时长
- 产品名称
- USP15 antibody
- 货号
- FNab09311
- 规格
- 100μg
- 状态
- liquid
- 纯化方法
- Immunogen affinity purified
- 纯度
- ≥95% as determined by SDS-PAGE
- 克隆性
- polyclonal
- 亚型
- IgG
- 存储
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
免疫原信息
- 免疫原
- ubiquitin specific peptidase 15
- 别称
- Deubiquitinating enzyme 15 antibody, KIAA0529 antibody, Ubiquitin thiolesterase 15 antibody, Unph 2 antibody, UNPH4 antibody, USP15 antibody
- UniProt ID
- Q9Y4E8
- 分子量
- 112 kDa
验证实验
- 验证实验
- ELISA, WB, IP
- 建议稀释比例
- WB: 1:500-1:5000; IP: 1:500-1:5000; IHC: 1:50-1:500
验证图片
mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab09311(USP15 Antibody) at dilution of 1:1000
IP Result of anti-USP15 (IP:FNab09311, 4ug; Detection:FNab09311 1:1000) with mouse brain tissue lysate 4000ug.
- 背景介绍
- Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling and NF-kappa-B pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs(SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes(PubMed:21947082). According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal(PubMed:22344298). Able to mediate deubiquitination of monoubiquitinated substrates as well as 'Lys-48'-linked polyubiquitin chains, protecting them against proteasomal degradation. May also regulate gene expression and/or DNA repair through the deubiquitination of histone H2B(PubMed:24526689). Acts as an associated component of COP9 signalosome complex(CSN) and regulates different pathways via this association: regulates NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP. Protects APC and human papillomavirus type 16 protein E6 against degradation via the ubiquitin proteasome pathway.
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