产品
本公司产品仅供体外研究使用，不用于临床诊断
USP19 antibody
¥2100
规格：
货期：
三个工作日+顺丰&京东快递时长
- 产品名称
- USP19 antibody
- 货号
- FNab09314
- 规格
- 100μg
- 状态
- liquid
- 纯化方法
- Immunogen affinity purified
- 纯度
- ≥95% as determined by SDS-PAGE
- 克隆性
- polyclonal
- 亚型
- IgG
- 存储
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
免疫原信息
- 免疫原
- ubiquitin specific peptidase 19
- 别称
- Deubiquitinating enzyme 19 antibody, KIAA0891 antibody, Ubiquitin thiolesterase 19 antibody, USP19 antibody, ZMYND9 antibody
- UniProt ID
- O94966
- 分子量
- 70 kDa, 160 kDa
验证实验
- 验证实验
- ELISA, WB
- 建议稀释比例
- WB: 1:500-1:2000
验证图片
Various lysates were subjected to SDS PAGE followed by western blot with FNab09314(USP19 Antibody) at dilution of 1:1000
- 背景介绍
- Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation(ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non-catalytic manner. Plays an important role in 17 beta-estradiol(E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards 'Lys-63'-linked Ubiquitin chains.
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