产品
本公司产品仅供体外研究使用，不用于临床诊断
RANKL antibody
¥1900
规格：
货期：
三个工作日+顺丰&京东快递时长
- 产品名称
- RANKL antibody
- 货号
- FNab09838
- 规格
- 100μg
- 状态
- liquid
- 纯化方法
- Protein A+G purification
- 纯度
- ≥95% as determined by SDS-PAGE
- 克隆性
- monoclonal
- 亚型
- IgG1
- Clone ID
- 4F11
- 存储
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
免疫原信息
- 免疫原
- tumor necrosis factor (ligand) superfamily, member 11
- 别称
- CD254 antibody, hRANKL2 antibody, ODF antibody, OPGL antibody, OPTB2 antibody, Osteoprotegerin ligand antibody, RANKL antibody, sOdf antibody, TNFSF11 antibody, TRANCE antibody
- UniProt ID
- O14788
- 分子量
- 35 kDa
验证实验
- 验证实验
- ELISA, WB
- 建议稀释比例
- WB: 1:1000-1:5000
验证图片
Hela cells were subjected to SDS PAGE followed by western blot with FNab09838(RANKL antibody) at dilution of 1:3000
- 背景介绍
- TNFSF11 also known as RANKL, is a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. RANKL induces osteoclast formation through its receptor, RANK, which transduces signals by recruiting adaptor molecules, such as the TNF receptor-associated factor (TRAF) family of proteins. RANKL was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. RANKL was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis.
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