HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab09853(SQSTM1 antibody) at dilution of 1:2000
Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using FNab09853(SQSTM1 Antibody) at dilution of 1:100
背景介绍
This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.