产品
本公司产品仅供体外研究使用，不用于临床诊断
c-Kit/CD117 antibody
¥1900
规格：
货期：
三个工作日+顺丰&京东快递时长
- 产品名称
- c-Kit/CD117 antibody
- 货号
- FNab09971
- 规格
- 100μg
- 状态
- liquid
- 纯化方法
- Immunogen affinity purified
- 纯度
- ≥95% as determined by SDS-PAGE
- 克隆性
- polyclonal
- 亚型
- IgG
- 存储
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
免疫原信息
- 免疫原
- Mast/stem cell growth factor receptor Kit
- 别称
- C Kit antibody, CD117 antibody, KIT antibody, PBT antibody, Proto oncogene c Kit antibody, SCFR antibody, Tyrosine protein kinase Kit antibody
- UniProt ID
- P10721
- 分子量
- 120 kDa, 145 kDa
验证实验
- 验证实验
- ELISA, WB, IHC
- 建议稀释比例
- WB: 1:200-1:2000; IHC: 1:50-1:200
验证图片
MCF7 cells were subjected to SDS PAGE followed by western blot with FNab09971(c-Kit/CD117 antibody) at dilution of 1:200
Immunohistochemistry of paraffin-embedded rat ovary tissue slide using FNab09971(C-KIT Antibody) at dilution of 1:100
- 背景介绍
- Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK(isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1.
抗体定制服务
抗体定制服务
