产品
本公司产品仅供体外研究使用，不用于临床诊断
STAT1 antibody
¥1500
规格：
货期：
三个工作日+顺丰&京东快递时长
- 产品名称
- STAT1 antibody
- 货号
- FNab09985
- 规格
- 100μg
- 状态
- liquid
- 纯化方法
- Immunogen affinity purified
- 纯度
- ≥95% as determined by SDS-PAGE
- 克隆性
- polyclonal
- 亚型
- IgG
- 存储
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
免疫原信息
- 免疫原
- signal transducer and activator of transcription 1, 91kDa
- 别称
- ISGF 3 antibody, STAT1 antibody, STAT91 antibody
- UniProt ID
- P42224
- 分子量
- 84 kDa
验证实验
- 验证实验
- ELISA, WB, IHC
- 建议稀释比例
- WB: 1:500-1:2000; IHC: 1:50-1:500
验证图片
Rat liver tissue were subjected to SDS PAGE followed by western blot with FNab09985(STAT1 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using FNab09985(STAT1 Antibody) at dilution of 1:200
- 背景介绍
- Signal transducer and transcription activator that mediates cellular responses to interferons(IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN(IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases(TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element(ISRE) to activate the transcription of IFN-stimulated genes(ISG), which drive the cell in an antiviral state. In response to type II IFN(IFN-gamma), STAT1 is tyrosine-and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor(GAF), migrates into the nucleus and binds to the IFN gamma activated sequence(GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.
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