产品
本公司产品仅供体外研究使用，不用于临床诊断
CADM1 antibody
¥1500
规格：
货期：
三个工作日+顺丰快递时长
- 产品名称
- CADM1 antibody
- 货号
- FNab10751
- 规格
- 100μg
- 状态
- liquid
- 纯化方法
- Immunogen affinity purified
- 纯度
- ≥95% as determined by SDS-PAGE
- 克隆性
- polyclonal
- 亚型
- IgG
- 存储
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
免疫原信息
- 免疫原
- cell adhesion molecule 1
- 别称
- IGSF4 antibody, IGSF4A antibody, antibody
- UniProt ID
- Q9BY67
- 分子量
- 49-67 kDa
验证实验
- 验证实验
- ELISA, WB, IHC
- 建议稀释比例
- WB: 1:500-1:2000; IHC: 1:50-1:200
验证图片
A549 cell lysates were subjected to SDS PAGE followed by western blot with FNab10751(CADM1 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded rat brain tissue slide using FNab10751(CADM1 antibody) at dilution of 1:100
- 背景介绍
- Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer(NSCLC) cells. Interaction with CRTAM promotes natural killer(NK) cell cytotoxicity and interferon-gamma(IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly(By similarity). May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.
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