1.白细胞介素17结构
白细胞介素17A，也称为CTLA-8，是一种15-20kDa糖基化细胞因子，在抗微生物和慢性炎症中发挥重要作用。六种IL-17细胞因子(IL-17A-F)由不同的基因编码，但采用保守的胱氨酸结折叠。成熟的人IL-17A与小鼠和大鼠IL-17A具有60%的氨基酸序列同一性。
2.白细胞介素17来源
IL-17A由Th17细胞、γ/δT细胞、iNKT细胞、NK细胞、LTi细胞、中性粒细胞和肠道潘氏细胞分泌。它与IL-17F形成
二硫键连接的同二聚体和二硫键连接的异二聚体。IL-17A通过与IL-17RC或IL-17RD复合的跨膜IL-17RA发挥作用。IL-17RA和IL-17RC都是对异二聚体IL-17A/F的反应所必需的。
3.白细胞介素17作用
IL-17A促进保护性粘膜和表皮炎症以应对微生物感染。它诱导趋化因子产生、中性粒细胞流入和抗菌肽的产生。IL-17A/F同样会诱导中性粒细胞迁移，但IL-17F不会。
IL-17A还可增强类风湿性滑膜成纤维细胞产生的炎症介质，并促进TNF-α诱导的休克。相反，它可以通过限制慢性炎症来防止结肠炎的进展。IL-17A促进自身反应性生发中心的形成，并加剧自身免疫实验模型的发生和发展。IL-17A已被证明具有致瘤或抗肿瘤作用。
菲恩生物研发相关产品：
|
货号 |
产品名称 |
灵敏度 |
检测范围 |
|
EB1001 |
9.375pg/ml |
15.625-1000pg/ml |
|
|
ECA0032 |
18.75pg/ml |
31.25-2000pg/ml |
|
|
ECH0038 |
9.375pg/ml |
15.625-1000pg/ml |
|
|
EGP0028 |
18.75pg/ml |
31.25-2000pg/ml |
|
|
EHA0007 |
18.75pg/ml |
31.25-2000pg/ml |
|
|
AQ-H3267-B |
3.75pg/ml |
6.25-400pg/ml |
|
|
EH3267 |
18.75pg/ml |
31.25-2000pg/ml |
|
|
EH4461 |
18.75pg/ml |
31.25-2000pg/ml |
|
|
EH2104 |
9.375pg/ml |
15.625-1000pg/ml |
|
|
EH2513 |
9.375pg/ml |
15.625-1000pg/ml |
|
|
EH4328 |
9.375pg/ml |
15.625-1000pg/ml |
|
|
EH4871 |
46.875pg/ml |
78.125-5000pg/ml |
|
|
EH0793 |
0.094ng/ml |
0.156-10ng/ml |
|
|
EMK0186 |
9.375pg/ml |
15.625-1000pg/ml |
|
|
EM1624 |
4.688pg/ml |
7.813-500pg/ml |
|
|
EM1946 |
18.75pg/ml |
31.25-2000pg/ml |
|
|
EM1915 |
9.375pg/ml |
15.625-1000pg/ml |
|
|
EP0090 |
9.375pg/ml |
15.625-1000pg/ml |
|
|
ERB0160 |
9.375pg/ml |
15.625-1000pg/ml |
|
|
ER0035 |
9.375pg/ml |
15.625-1000pg/ml |
蛋白：
|
货号 |
产品名称 |
宿主 |
区间 |
分子量 |
标签 |
|
P1413 |
E.Coli |
26-158 |
17 KDa |
N-terminal His Tag |
|
|
P0797 |
E.Coli |
24-155 |
17 KDa |
N-terminal His Tag |
|
|
P6923 |
E.Coli |
21-180 |
17.5 kDa |
N-terminal His Tag |
|
|
P6226 |
E.Coli |
18-202 |
20.2 kDa |
N-terminal His Tag |
|
|
P6460 |
E.Coli |
31-163 |
14.5 kDa |
N-terminal His Tag |
|
|
P2006 |
E.Coli |
317-494 |
40.9 kDa |
N-terminal His-IF2DI Tag |
|
|
P8881 |
E.Coli |
26-158 |
35.6 KDa |
N-terminal His-IF2DI Tag |
|
|
P5991 |
E.Coli |
26-158 |
14.5 kDa |
N-terminal His Tag |
|
|
P6093 |
E.Coli |
29-161 |
14.5 kDa |
N-terminal His Tag |
|
|
P5948 |
E.Coli |
28-161 |
14.6 kDa |
N-terminal His Tag |
抗体：
|
货号 |
产品名称 |
宿主 |
克隆性 |
适用种属 |
验证应用 |
|
FNab04224 |
Rabbit |
polyclonal |
Human, Mouse, Rat |
ELISA, WB, IHC |
|
|
FNab04225 |
Mouse |
monoclonal |
Human |
ELISA, WB, FC |
|
|
FNab04227 |
Mouse |
monoclonal |
Human |
ELISA, WB |
|
|
FNab04228 |
Rabbit |
polyclonal |
Human |
ELISA, WB |
|
|
FNab04229 |
Mouse |
monoclonal |
Human, Mouse |
ELISA, WB |
|
|
FNab09773 |
Rabbit |
polyclonal |
Human, Mouse, Rat |
ELISA, WB |
|
|
FNab04230 |
Rabbit |
polyclonal |
Human, Mouse |
ELISA, WB, IHC, IF, IP |
|
|
FNab04231 |
Rabbit |
polyclonal |
Human, Mouse |
ELISA, WB |
|
|
FNab04232 |
Rabbit |
polyclonal |
Human |
ELISA, WB, IHC |