产品
本公司产品仅供体外研究使用，不用于临床诊断
Beclin 1 antibody
¥2100
规格：
货期：
三个工作日+顺丰&京东快递时长
- 产品名称
- Beclin 1 antibody
- 货号
- FNab10873
- 规格
- 100μg
- 状态
- liquid
- 纯化方法
- Protein A+G purification
- 纯度
- ≥95% as determined by SDS-PAGE
- 克隆性
- monoclonal
- 亚型
- IgG1
- Clone ID
- 1G5
- 存储
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
免疫原信息
- 免疫原
- beclin 1, autophagy related
- 别称
- ATG6 antibody, Beclin 1 antibody, beclin 1 antibody, autophagy related antibody, beclin1 antibody, BECN1 antibody, GT197 antibody, Protein GT197 antibody, VPS30 antibody
- UniProt ID
- Q14457
- 分子量
- 60 kDa
验证实验
- 验证实验
- ELISA, IHC, WB
- 建议稀释比例
- WB: 1:500 - 1:5000; IHC: 1:50 - 1:200
验证图片
Hela cells were subjected to SDS PAGE followed by western blot with FNab10873(Beclin 1 Antibody) at dilution of 1:3000
Immunohistochemistry of paraffin-embedded human breast cancer using FNab10873(Beclin 1 antibody) at dilution of 1:100
- 背景介绍
- Beclin-1(BECN1), also known as ATG6 or VPS30, has a central role in autophagy, a process of programmed cell survival, which is increased during periods of cell stress and extinguished during the cell cycle. Beclin-1, may play a role in antiviral host defense. It protects against infection by a neurovirulent strain of Sindbis virus. Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration. A progressively reduced Beclin-1 expression is reported to correlate with the primary tumor growth of squamous cell carcinoma and adenocarcinoma of the lung. Caspase-mediated cleavage of Beclin 1 promotes crosstalk between apoptosis and autophagy.
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