产品
本公司产品仅供体外研究使用,不用于临床诊断
- 产品介绍
- 相关文献
- 产品名称
- GPX4 antibody
- 货号
- FNab03622
- 规格
- 100μg
- 状态
- liquid
- 纯化方法
- Immunogen affinity purified
- 纯度
- ≥95% as determined by SDS-PAGE
- 克隆性
- polyclonal
- 亚型
- IgG
- 存储
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
免疫原信息
- 免疫原
- glutathione peroxidase 4 (phospholipid hydroperoxidase)
- UniProt ID
- P36969
- 分子量
- 25 kDa
验证实验
- 验证实验
- ELISA, WB, IHC, IF
- 建议稀释比例
- WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200
验证图片
mouse kidney tissue were subjected to SDS PAGE followed by western blot with FNab03622(GPX4 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human liver injury using FNab03622(GPX4 antibody) at dilution of 1:50
- 背景介绍
- The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development; thus, it has been identified as a 'moonlighting' protein because of its ability to serve dual functions as a peroxidase, as well as a structural protein in mature spermatozoa. Mutations in this gene are associated with Sedaghatian type of spondylometaphyseal dysplasia (SMDS). This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene.
IF: 3.9
- 期刊名:
- BMC Complementary Medicine and Therapies
- 作者:
- 广东省中医院(广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院、广东省中医药研修院)
- 发布日期:
- 2023-12-08
- 引用产品:
IF: 3.2
- 期刊名:
- Toxicology in Vitro
- 作者:
- 土耳其安卡拉大学
- 发布日期:
- 2023-11-17
- 引用产品: