产品
本公司产品仅供体外研究使用，不用于临床诊断
HMGCR antibody
¥1750
规格：
货期：
三个工作日+顺丰快递时长
- 产品名称
- HMGCR antibody
- 货号
- FNab03929
- 规格
- 100μg
- 状态
- liquid
- 纯化方法
- Immunogen affinity purified
- 纯度
- ≥95% as determined by SDS-PAGE
- 克隆性
- polyclonal
- 亚型
- IgG
- 存储
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
免疫原信息
- 免疫原
- 3-hydroxy-3-methylglutaryl-Coenzyme A reductase
- 别称
- HMG CoA reductase antibody, HMGCR antibody, 3-hydroxy-3-methylglutaryl-coenzyme A reductase antibody, HMDH antibody
- UniProt ID
- P04035
- 分子量
- 100 kDa
验证实验
- 验证实验
- ELISA, WB, IHC, IF
- 建议稀释比例
- WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200
验证图片
HeLa cells were subjected to SDS PAGE followed by western blot with FNab03929(HMGCR antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human breast cancer using FNab03929(HMGCR antibody) at dilution of 1:100
- 背景介绍
- HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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