产品
本公司产品仅供体外研究使用，不用于临床诊断
SIRT6 antibody
¥1900
规格：
货期：
三个工作日+顺丰快递时长
- 产品名称
- SIRT6 antibody
- 货号
- FNab07884
- 规格
- 100μg
- 状态
- liquid
- 纯化方法
- Immunogen affinity purified
- 纯度
- ≥95% as determined by SDS-PAGE
- 克隆性
- polyclonal
- 亚型
- IgG
- 存储
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
免疫原信息
- 免疫原
- sirtuin(silent mating type information regulation 2 homolog) 6
- 别称
- SIR2 like protein 6 antibody, SIR2L6 antibody, SIRT6 antibody
- UniProt ID
- Q8N6T7
- 分子量
- 49kd
验证实验
- 验证实验
- ELISA, WB, IHC
- 建议稀释比例
- WB: 1:200-1:2000; IHC: 1:50-1:200
验证图片
HeLa cells were subjected to SDS PAGE followed by western blot with FNab07884(SIRT6 antibody) at dilution of 1:400
Immunohistochemistry of paraffin-embedded human brain using FNab07884(SIRT6 antibody) at dilution of 1:50
- 背景介绍
- NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span(By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate.
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