产品
本公司产品仅供体外研究使用，不用于临床诊断
NFKB1 antibody
¥1500
规格：
货期：
三个工作日+顺丰快递时长
- 产品名称
- NFKB1 antibody
- 货号
- FNab10334
- 规格
- 100μg
- 状态
- liquid
- 纯化方法
- Immunogen affinity purified
- 纯度
- ≥95% as determined by SDS-PAGE
- 克隆性
- polyclonal
- 亚型
- IgG
- 存储
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
免疫原信息
- 免疫原
- nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
- 别称
- DNA binding factor KBF1 antibody, EBP 1 antibody, KBF1 antibody, NF kappa B antibody, NFKB p105 antibody, NFKB p50 antibody, NFKB1 antibody, NFKB1 antibody, p105 antibody, NFKB1 antibody, p105 antibody, p50 antibody, nfkb1a antibody, p105 antibody, p50 antibody
- UniProt ID
- P19838
- 分子量
- 50 kDa,105 kDa
验证实验
- 验证实验
- ELISA, WB, IHC
- 建议稀释比例
- WB: 1:200-1:2000; IHC: 1:50-1:500
验证图片
Jurkat cells were subjected to SDS PAGE followed by western blot with FNab10334(NFKB1 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded rat lung using FNab10334(NFKB1 antibody) at dilution of 1:100
- 背景介绍
- This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed.
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