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Acetylated tubulin (Lys40) antibody
| 规格 | 价格 |
|---|---|
| 100μg | RMB ¥1900 |
| 50μg | RMB ¥1140 |
货期：
三个工作日+顺丰快递时长
- 产品名称
- Acetylated tubulin (Lys40) antibody
- 货号
- FNab00082
- 规格
- 100μg
- 状态
- liquid
- 纯化方法
- Protein A+G purification
- 纯度
- ≥95% as determined by SDS-PAGE
- 克隆性
- monoclonal
- 亚型
- IgG1
- Clone ID
- 6A10
- 存储
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
免疫原信息
- 免疫原
- tubulin, alpha 1a
- 别称
- Tubulin alpha-1A chain|Alpha-tubulin 3|Tubulin B-alpha-1|Tubulin alpha-3 chain|Detyrosinated tubulin alpha-1A chain|TUBA1A|TUBA3 antibody
- UniProt ID
- Q71U36
- 分子量
- 52 kDa
验证实验
- 验证实验
- ELISA, WB, IHC, IF
- 建议稀释比例
- WB: 1:500-1:5000; IF: 1:20-1:200; IHC: 1:20-1:200
验证图片
L02 cells were subjected to SDS PAGE followed by western blot with FNab00082(Acetylated tubulin(Lys40) Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using FNab00082(Acetylated tubulin(Lys40) Antibody) at dilution of 1:50
- 背景介绍
- Tubulin, composed of heterodimers of alpha and beta tubulin, is the mainly component of microtubules which play important roles in cell motility, mitosis, and intracellular vesicle transport. Both alpha and beta tubulin undergo several posttranslational modifications such as polyglutamylation and acetylation/deacetylation. Tubulin acetylation occurs on lysine-40 at the N-terminal of alpha tubulin and is conserved across species. The histone deacetylase HDAC6 and SIRT2 has been identified as tubulin deacetylases. Reversible acetylation of alpha tubulin may be implicated in regulating microtubule stability, cell motility, and axon regeneration. The level of acetylated tubulin has been linked to epithelial malignancies and sensitivity to chemotherapy. In addition, acetylated tubulin has been widely used as a marker for primary cilia. This antibody is specific to the acetylated tubulin; it does not recognize non-acetylated tubulin.
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