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AIF antibody

分类：

研究方向：

别称：	AIF antibody, AIFM1 antibody, PDCD8 antibody
货号：	FNab00235	反应性：	Human, Mouse
宿主：	Rabbit	验证实验：	ELISA, IHC, WB, IF
克隆性：	polyclonal	亚型：	IgG

说明书 MSDS

¥1750

规格：

货期：三个工作日+顺丰快递时长

产品名称: AIF antibody
货号: FNab00235
规格: 100μg
状态: liquid
纯化方法: Immunogen affinity purified
纯度: ≥95% as determined by SDS-PAGE
克隆性: polyclonal
亚型: IgG
存储: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

免疫原信息

验证实验

验证图片

Jurkat cells were subjected to SDS PAGE followed by western blot with FNab00235(AIF antibody) at dilution of 1:1000

Immunohistochemistry of paraffin-embedded human esophagus tissue slide using FNab00235( AIF Antibody) at dilution of 1:100

Immunofluorescence analysis of U2OS cells using FNab00235( AIF Antibody). Blue: DAPI for nuclear staining.

背景介绍: This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6 (COXPD6), a severe mitochondrial encephalomyopathy, as well as Cowchock syndrome, also known as X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4), a disorder resulting in neuropathy, and axonal and motor-sensory defects with deafness and mental retardation. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10.