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AKAP8L antibody
| 规格 | 价格 |
|---|---|
| 100μg | RMB ¥1750 |
| 50μg | RMB ¥1050 |
货期：
三个工作日+顺丰快递时长
- 产品名称
- AKAP8L antibody
- 货号
- FNab00258
- 规格
- 100μg
- 状态
- liquid
- 纯化方法
- Immunogen affinity purified
- 纯度
- ≥95% as determined by SDS-PAGE
- 克隆性
- polyclonal
- 亚型
- IgG
- 存储
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
免疫原信息
- 免疫原
- A kinase(PRKA) anchor protein 8-like
- 别称
- A-kinase anchor protein 8-like (AKAP8-like protein)|Helicase A-binding protein 95 (HAP95)|Homologous to AKAP95 protein (HA95)|Neighbor of A-kinase-anchoring protein 95 (Neighbor of AKAP95)|AKAP8L|NAKAP|NAKAP95 antibody
- UniProt ID
- Q9ULX6
- 分子量
- 72 kDa
验证实验
- 验证实验
- ELISA, WB, IF
- 建议稀释比例
- WB: 1:200-1:2000; IF: 1:20-200
验证图片
PC-3 cells were subjected to SDS PAGE followed by western blot with FNab00258(AKAP8L Antibody) at dilution of 1:300
- 背景介绍
- Could play a role in constitutive transport element(CTE)-mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export(PubMed:10748171, PubMed:11402034). Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA(PubMed:10761695, PubMed:11884601). May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis(PubMed:11034899). May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta(PubMed:12538639). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function seems to act redundantly with AKAP8(PubMed:16980585). May be involved in regulation of pre-mRNA splicing(PubMed:17594903). (Microbial infection) In case of EBV infection, may target PRKACA to EBNA-LP-containing nuclear sites to modulate transcription from specific promoters(PubMed:11884601). Can synergize with DHX9 to activate the CTE-mediated gene expression of type D retroviruses(PubMed:11402034). In case of HIV-1 infection, involved in the DHX9-promoted annealing of host tRNA(Lys3) to viral genomic RNA as a primer in reverse transcription; in vitro negatively regulates DHX9 annealing activity(PubMed:25034436).
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