产品
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SERPINA1 antibody
| 规格 | 价格 |
|---|---|
| 100μg | RMB ¥2100 |
| 50μg | RMB ¥1260 |
货期：
三个工作日+顺丰快递时长
- 产品名称
- SERPINA1 antibody
- 货号
- FNab00338
- 规格
- 100μg
- 状态
- liquid
- 纯化方法
- Protein A+G purification
- 纯度
- ≥95% as determined by SDS-PAGE
- 克隆性
- monoclonal
- 亚型
- IgG1
- Clone ID
- 5B1
- 存储
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
免疫原信息
- 免疫原
- serpin peptidase inhibitor, clade A(alpha-1 antiproteinase, antitrypsin), member 1
- 别称
- Alpha-1-antitrypsin|Alpha-1 protease inhibitor|Alpha-1-antiproteinase|Serpin A1|Short peptide from AAT (SPAAT)|SERPINA1|AAT|PI antibody
- UniProt ID
- P01009
- 分子量
- 50 kDa
验证实验
- 验证实验
- ELISA, WB, IHC, IF
- 建议稀释比例
- WB: 1:500-1:5000; IP: 1:500-1:2000; IF: 1:20-1:200; IHC: 1:500-1:1000
验证图片
HepG2 cells were subjected to SDS PAGE followed by western blot with FNab00338(Alpha-1-Antitrypsin antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human liver using FNab00338(Alpha-1-Antitrypsin antibody) at dilution of 1:1000
Immunofluorescent analysis of HepG2 cells using FNab00338( Alpha-1-Antitrypsin Antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Mouse IgG(H+L)
- 背景介绍
- SERPINA1 is the gene for a protein called alpha-1-antitrypsin(AAT), which is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. AAT is a glycoprotein synthesized primarily by hepatocytes, with smaller amountssynthesized by intestinal epithelial cells, neutrophils, pulmonary alveolar cells and macrophages. AAT is the most abundant, endogenous serine protease inhibitor in blood circulation and it has been implicated in regulating vital fluid phase biological events such as blood coagulation, fibrinolysis, complement activation, apoptosis, reproduction, tumor progression and inflammatory response. The primary function of AAT is thought to be the inactivation of neutrophil elastase and other endogenous serine proteases. Defects in SERPINA1 can cause emphysema or liver disease.
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