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APOBEC3G antibody
| 规格 | 价格 |
|---|---|
| 100μg | RMB ¥1900 |
| 50μg | RMB ¥1140 |
货期：
三个工作日+顺丰快递时长
- 产品名称
- APOBEC3G antibody
- 货号
- FNab00495
- 规格
- 100μg
- 状态
- liquid
- 纯化方法
- Immunogen affinity purified
- 纯度
- ≥95% as determined by SDS-PAGE
- 克隆性
- polyclonal
- 亚型
- IgG
- 存储
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
免疫原信息
- 免疫原
- apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
- 别称
- DNA dC->dU-editing enzyme APOBEC-3G|APOBEC-related cytidine deaminase (APOBEC-related protein antibody, ARCD)|APOBEC-related protein 9 (ARP-9)|CEM-15 (CEM15)|Deoxycytidine deaminase (A3G)|APOBEC3G antibody
- UniProt ID
- Q9HC16
- 分子量
- 46 kDa
验证实验
- 验证实验
- ELISA, WB, IHC, IF
- 建议稀释比例
- WB: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:20-1:200
验证图片
mouse colon tissue were subjected to SDS PAGE followed by western blot with FNab00495(APOBEC3G Antibody) at dilution of 1:100
Immunohistochemistry of paraffin-embedded human testis tissue slide using FNab00495(APOBEC3G Antibody) at dilution of 1:200
Immunofluorescent analysis of MCF-7 cells using FNab00495 (APOBEC3G antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated Goat Anti-Rabbit IgG(H+L)
- 背景介绍
- DNA deaminase(cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and-independent mechanisms. Exhibits potent antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity also against simian immunodeficiency viruses(SIVs), hepatitis B virus(HBV), equine infectious anemia virus(EIAV), xenotropic MuLV-related virus(XMRV) and simian foamy virus(SFV). May inhibit the mobility of LTR and non-LTR retrotransposons.
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