HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab00520(AQR Antibody) at dilution of 1:1500
Immunohistochemistry of paraffin-embedded human brain slide using FNab00520(AQR Antibody) at dilution of 1:50
背景介绍
Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP(small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns(40 nucleotides upstream of the branchpoint) during the late stages of splicing.