Immunohistochemistry of paraffin-embedded human colon tissue slide using FNab00523(ARAP3 Antibody) at dilution of 1:50
背景介绍
Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate(PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate(PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin.