Protein CBFA2T3|MTG8-related protein 2|Myeloid translocation gene on chromosome 16 protein (hMTG16)|Zinc finger MYND domain-containing protein 4|CBFA2T3|MTG16|MTGR2|ZMYND4 antibody
货号:
FNab01316
反应性:
Human, Mouse, Rat
宿主:
Rabbit
验证实验:
ELISA, WB
克隆性:
polyclonal
亚型:
IgG
规格
价格
100μg
RMB ¥1900
50μg
RMB ¥1140
货期:
三个工作日+顺丰快递时长
产品介绍
实验结果
实验条件
常见问题
产品名称
CBFA2T3 antibody
货号
FNab01316
规格
100μg
状态
liquid
纯化方法
Immunogen affinity purified
纯度
≥95% as determined by SDS-PAGE
克隆性
polyclonal
亚型
IgG
存储
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
免疫原信息
免疫原
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
别称
Protein CBFA2T3|MTG8-related protein 2|Myeloid translocation gene on chromosome 16 protein (hMTG16)|Zinc finger MYND domain-containing protein 4|CBFA2T3|MTG16|MTGR2|ZMYND4 antibody
Jurkat cells were subjected to SDS PAGE followed by western blot with FNab01316(CBFA2T3 antibody) at dilution of 1:1000
背景介绍
Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes(PubMed:12559562, PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner(PubMed:23251453). Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway(PubMed:25974097). Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A(PubMed:23840896, PubMed:25974097). Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes(By similarity). Plays a role in granulocyte differentiation(PubMed:15231665). Isoform 2 functions as an A-kinase-anchoring protein(PubMed:11823486).