Coiled-coil and C2 domain-containing protein 1A|Akt kinase-interacting protein 1|Five prime repressor element under dual repression-binding protein 1 (FRE under dual repression-binding protein 1 antibody, Freud-1)|Putative NF-kappa-B-activating protein 023N|CC2D1A|AKI1 antibody
货号:
FNab01335
反应性:
Human, Mouse, Rat
宿主:
Rabbit
验证实验:
ELISA, WB, IHC, IF
克隆性:
polyclonal
亚型:
IgG
规格
价格
100μg
RMB ¥1750
50μg
RMB ¥1050
货期:
三个工作日+顺丰快递时长
产品介绍
实验结果
实验条件
常见问题
产品名称
CC2D1A antibody
货号
FNab01335
规格
100μg
状态
liquid
纯化方法
Immunogen affinity purified
纯度
≥95% as determined by SDS-PAGE
克隆性
polyclonal
亚型
IgG
存储
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
免疫原信息
免疫原
coiled-coil and C2 domain containing 1A
别称
Coiled-coil and C2 domain-containing protein 1A|Akt kinase-interacting protein 1|Five prime repressor element under dual repression-binding protein 1 (FRE under dual repression-binding protein 1 antibody, Freud-1)|Putative NF-kappa-B-activating protein 023N|CC2D1A|AKI1 antibody
HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab01335(CC2D1A antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human testis using FNab01335(CC2D1A antibody) at dilution of 1:100
背景介绍
Transcription factor that binds specifically to the DRE(dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses(By similarity). Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis.