human placenta tissue were subjected to SDS PAGE followed by western blot with FNab01606(CEP63 antibody) at dilution of 1:800
IP Result of anti-CEP63 (IP:FNab01606, 3ug; Detection:FNab01606 1:500) with HEK-293 cells lysate 1700ug.
Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using FNab01606(CEP63 Antibody) at dilution of 1:50
背景介绍
Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Reported to be required for centrosomal recruitment of CEP152; however, this function has been questioned(PubMed:21983783, PubMed:26297806). Also recruits CDK1 to centrosomes(PubMed:21406398). Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks(DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression(PubMed:21406398).