mouse testis tissue were subjected to SDS PAGE followed by western blot with FNab01811(CNOT7 antibody) at dilution of 1:500
IP Result of anti-CNOT7 (IP:FNab01811, 4ug; Detection:FNab01811 1:300) with mouse testis tissue lysate 4800ug.
背景介绍
Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.