human heart tissue were subjected to SDS PAGE followed by western blot with FNab01873(COPS7A antibody) at dilution of 1:300
IP Result of anti-COPS7A (IP:FNab01873, 4ug; Detection:FNab01873 1:300) with mouse heart tissue lysate 4000ug.
Immunohistochemistry of paraffin-embedded human kidney using FNab01873(COPS7A antibody) at dilution of 1:50
背景介绍
Component of the COP9 signalosome complex(CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin(Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.